{"id":379,"date":"2021-12-10T12:20:19","date_gmt":"2021-12-10T12:20:19","guid":{"rendered":"https:\/\/healthypregnancy-ro-hu.oncogen.ro\/?page_id=379"},"modified":"2023-07-07T09:45:55","modified_gmt":"2023-07-07T09:45:55","slug":"pgd-pgs","status":"publish","type":"page","link":"https:\/\/healthypregnancy-ro-hu.oncogen.ro\/index.php\/pgd-pgs\/","title":{"rendered":"PGD & PGS"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

www.interreg-rohu.eu<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t

PGD & PGS<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

Preimplantation genetic diagnosis (PGD)<\/strong><\/p>

PGD is a genetic diagnosis technique that provides information about the gene structure of cells in an embryo<\/strong>.<\/p>

An embryonic biopsy<\/strong> is used \u2013 about 3 to 8 cells from a 5-day embryo (blastocyst stage). The harvested cells are sent to the laboratory for testing. After the biopsy, the embryo is frozen and preserved until transfer and implantation.<\/p>

The PGD \u200b\u200bis able to identify approximately 2,000 genetic diseases<\/strong>, it has 98% accuracy<\/strong> and it is used to identify healthy embryos<\/strong>. It \u200b\u200bis generally useful to couples with a family history of genetic diseases<\/strong> that can be inherited by their children.<\/p>

Specific markers of certain diseases<\/strong>, such as monogenic disorders, including cystic fibrosis and sickle cell disease, X chromosomal fragility, and Duchenne muscular dystrophy, can be identified<\/strong> by using the preimplantation genetic diagnosis technique.<\/p>

<\/p>

Preimplantation genetic screening (PGS)<\/strong><\/p>

PGS is used to determine whether the cells in an embryo have the normal number of chromosomes<\/strong> (46).<\/p>

A biopsy from a 5-day embryo (blastocyst stage) is used. The embryonic cells are then sent to a laboratory that uses the technique to identify the number of chromosomes in each cell<\/strong>. Embryos with a normal number of chromosomes are called „euploid” and those with an abnormal number are called „aneuploid”. The aim of PGS is to prevent the transfer of an abnormal embryo to the uterus<\/strong>.<\/p>

As all women\/men will have some eggs\/sperm that are chromosomally abnormal, all couples are at risk of having abnormal embryos. This risk significantly increases as a woman gets older.<\/p>

An abnormal embryo almost always fails to implant<\/strong> or, if it does, it ends with a biochemical pregnancy<\/strong> (hormonal evidence of pregnancy only), miscarriage<\/strong>, foetal death<\/strong> later during pregnancy, or birth of a child with severe health problems<\/strong>.<\/p>

Couples undergoing IVF<\/strong> (in vitro fertilization) can make use of PGS if they<\/strong>:<\/p>